A "neglected" market and high street are among plans to develop 15-minute neighbourhoods.
Green Street and Queen's Market are to follow the lead of cities including Paris, which is pioneering neighbourhoods where needs can be met a 15-minute walk or bike ride away from people's front doors.
Bollywood-themed events could be among attractions aimed at bringing people to the high street from across the capital and beyond.
In total, £170million in Covid-19 related grants and business rate relief is being pumped into businesses across Newham.
Stratford, Canning Town and Royal Docks received billions in private investment following the London 2012 Olympic Games. But now overlooked high streets and town centres, including Upton Park, have been promised a cash injection.
Mayor of Newham Rokhsana Fiaz said the emphasis is on making sure areas "too long neglected" get attention.
She underlined Queen's Market and Green Street's importance as a "vibrant" community and business hub, adding neither have seen this level of investment "in a generation".
"We remain committed to maintaining Queen's Market as the jewel in the crown," Ms Fiaz said.
Plans to redevelop Queen's Market with housing and a supermarket faced fierce opposition from traders and campaigners in 2006. Then mayor of London, Boris Johnson, rejected the proposal three years later.
Now views are being sought from traders and business owners about five market designs. The mayor vowed the area would not be gentrified.
A management and maintenance plan, which traders hope will address concerns about how the market is run and stalls allocated, is still being developed.
The mayor added the goal is to return the market to its glory days, but also modernise it and rebuild traders' trust in the council.
She ruled out the possibility of outsourcing or ceding control of the market to a developer.
The Sunday market will carry on with casual traders welcome, but a public consultation deadline on five different options to develop the market would not be extended again. The £5m of City Hall funding has to be used by 2023.
Sheltered housing would remain with the goal of seeing 50pc social homes built on the council-owned site.
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