Newham’s turnout in the EU referendum of 59.2 per cent was the lowest in the capital.

With every constituency officially declared, the proportion of eligible voters in the borough having their say is much lower than the national average of 72.16pc.

And while Newham’s voters preferred to remain in the European Union, with a margin of 53pc to 47pc, the nationwide result backed Brexit as the Leave campaign won by 52pc to 48pc.

The outcome prompted David Cameron, who was in the Remain camp, to announce his resignation as Prime Minister this morning.

With his voice appearing to break, Mr Cameron said: “I love this country and I feel honoured to have served it.”

He said he had informed the Queen of his decision to remain in place for the short term, but hand over to a new Prime Minister by the time of the Conservative annual conference in October.

The decision to leave the European Union could have a huge impact on Newham.

The proposed redevelopment of the Royal Docks includes a new business district set to create 20,000 jobs.

Chinese developer ABP has already secured planning permission, but if Europe’s financial market is less accessible it could see companies choosing to go elsewhere.

HSBC chairman Douglas Flint said: “We are today entering a new era for Britain and British business. The work to establish fresh terms of trade with our European and global partners will be complex and time consuming.”

Meanwhile, shares in housebuilding companies Taylor Wimpey and Persimmon fell within minutes of the FTSE 100 opening this morning.

The companies are involved in some of the borough’s major regeneration projects, including Chobham Manor at Queen Elizabeth Olympic Park.