Motorists have been warned to expect delays after a crash between a car and van on the A13.
Police, firefighters and paramedics were called to reports of the collision at a westbound stretch of the Beckton flyover at about 3.41am today.
A Met spokeswoman said: "The van hit the central reservation. Two women and a man have been taken to hospital."
Two fire engines from Ilford and Leytonstone stations and a fire rescue unit from East Ham were also at the scene with firefighters releasing three people who were trapped.
The incident was over for firefighters by 5.16am.
TfL warned drivers that traffic is heavy and slow on approach with tailbacks beyond Beckton roundabout. Motorists were warned to expect delays.
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